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Daniel J Klionsky Selected Research

dolichyl-diphosphooligosaccharide - protein glycotransferase (oligosaccharyltransferase)

1/2022Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency.

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Daniel J Klionsky Research Topics

Disease

40Starvation
04/2022 - 02/2003
22Neoplasms (Cancer)
06/2022 - 07/2011
5Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 01/2007
5Infections
11/2021 - 01/2009
5COVID-19
12/2020 - 12/2020
4Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
05/2022 - 11/2016
4Hypoxia (Hypoxemia)
01/2022 - 01/2016
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2022 - 01/2020
2Systemic Lupus Erythematosus (Libman-Sacks Disease)
11/2022 - 01/2019
2Hepatocellular Carcinoma (Hepatoma)
11/2022 - 10/2008
2Renal Cell Carcinoma (Grawitz Tumor)
11/2022 - 01/2021
2Parkinson Disease (Parkinson's Disease)
07/2022 - 12/2016
2Choroidal Neovascularization
05/2022 - 01/2015
2Prostatic Neoplasms (Prostate Cancer)
03/2022 - 01/2021
2Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 01/2013
2Pancreatic Neoplasms (Pancreatic Cancer)
11/2021 - 01/2021
2Adenocarcinoma
11/2021 - 01/2021
2Sepsis (Septicemia)
12/2020 - 12/2016
2Lymphoma (Lymphomas)
01/2019 - 11/2016
2Retinal Degeneration
01/2018 - 12/2016
1Chronic Obstructive Pulmonary Disease (COPD)
11/2022
1Frontotemporal Dementia (Semantic Dementia)
11/2022
1Crohn Disease (Crohn's Disease)
11/2022
1Squamous Cell Carcinoma of Head and Neck
11/2022
1Adenocarcinoma of Lung
11/2022
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2022
1Retinoblastoma (Glioblastoma, Retinal)
06/2022
1Glucose Intolerance
05/2022
1Macular Degeneration (Age-Related Maculopathy)
05/2022
1Fibrosis (Cirrhosis)
05/2022
1Esophageal Neoplasms (Esophageal Cancer)
05/2022

Drug/Important Bio-Agent (IBA)

33Proteins (Proteins, Gene)FDA Link
07/2022 - 12/2006
19NitrogenIBA
04/2022 - 02/2003
10Phosphotransferases (Kinase)IBA
11/2022 - 10/2006
7Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
11/2022 - 01/2019
7Messenger RNA (mRNA)IBA
12/2020 - 07/2015
6Proton-Translocating ATPases (ATPase, H+)IBA
05/2022 - 01/2019
6Beclin-1IBA
05/2022 - 06/2014
6Sirolimus (Rapamycin)FDA Link
05/2022 - 01/2015
6Amino AcidsFDA Link
01/2022 - 12/2006
6IronIBA
01/2022 - 01/2018
5Glucose (Dextrose)FDA LinkGeneric
05/2022 - 11/2015
5Adenosine Triphosphatases (ATPase)IBA
05/2022 - 07/2013
5Chloroquine (Aralen)FDA LinkGeneric
11/2021 - 12/2020
4Reactive Oxygen Species (Oxygen Radicals)IBA
07/2022 - 01/2021
4Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA
05/2022 - 01/2019
4HMGB1 Protein (HMG1)IBA
05/2022 - 12/2016
4Proteasome Endopeptidase Complex (Proteasome)IBA
05/2022 - 01/2016
4Protein AggregatesIBA
01/2022 - 01/2007
3phosphatidylethanolamineIBA
11/2022 - 12/2020
3UbiquitinIBA
05/2022 - 01/2021
3Biological ProductsIBA
11/2021 - 11/2016
3AMP-Activated Protein KinasesIBA
11/2021 - 01/2017
3Fatty Acids (Saturated Fatty Acids)IBA
01/2021 - 01/2020
3Mechanistic Target of Rapamycin Complex 1IBA
01/2020 - 07/2011
3Carrier Proteins (Binding Protein)IBA
08/2019 - 07/2015
3InflammasomesIBA
01/2019 - 12/2016
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
11/2022 - 11/2021
2Untranslated Regions (Untranslated Region)IBA
11/2022 - 01/2021
2Pharmaceutical PreparationsIBA
06/2022 - 12/2020
2InterleukinsIBA
05/2022 - 12/2020
2gamma-Aminobutyric Acid (GABA)IBA
05/2022 - 01/2021
2Lysosomal-Associated Membrane Protein 2IBA
05/2022 - 01/2021
2RNA (Ribonucleic Acid)IBA
01/2022 - 01/2019
2CytokinesIBA
01/2022 - 11/2021
2MethyltransferasesIBA
01/2022 - 12/2019
2Arginine (L-Arginine)FDA Link
01/2022 - 12/2019
2AminopeptidasesIBA
01/2022 - 01/2019
2LipidsIBA
10/2021 - 01/2020
2Glutathione (Reduced Glutathione)IBA
01/2021 - 01/2019
2Antiviral Agents (Antivirals)IBA
01/2021 - 01/2019
2Transcription Factors (Transcription Factor)IBA
01/2021 - 01/2021
2Interferon-alpha (Interferon Alfa)IBA
01/2021 - 01/2019
2Cathepsin DIBA
01/2021 - 01/2019
2Peptide Hydrolases (Proteases)FDA Link
12/2020 - 04/2010
2Eukaryotic Initiation Factor-4EIBA
12/2019 - 01/2019
2Leucine (L-Leucine)FDA Link
01/2019 - 01/2019
2DNA (Deoxyribonucleic Acid)IBA
10/2017 - 11/2015
2TrehaloseIBA
10/2014 - 07/2007
2Hormones (Hormone)IBA
03/2003 - 02/2003
1Phosphatidylinositols (Phosphatidylinositol)IBA
11/2022
1phosphatidylinositol 3-phosphateIBA
11/2022
1Phosphates (Orthophosphate)IBA
11/2022
1amphiphysinIBA
07/2022
1ProhibitinsIBA
07/2022
1Casein Kinase II (Casein Kinase 2)IBA
07/2022
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
07/2022
1Carboplatin (JM8)FDA LinkGeneric
06/2022
1Transforming Growth Factor beta (TGF-beta)IBA
05/2022
1Amyloid beta-PeptidesIBA
05/2022
1NF-kappa B (NF-kB)IBA
05/2022
1Kelch-Like ECH-Associated Protein 1IBA
05/2022
1Prokaryotic Initiation Factor-2IBA
05/2022
1VimentinIBA
05/2022
1Cyclin-Dependent Kinase Inhibitor p16IBA
05/2022
1Threonine (L-Threonine)FDA Link
05/2022
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
05/2022

Therapy/Procedure

11Therapeutics
03/2022 - 01/2016
2Drug Therapy (Chemotherapy)
03/2022 - 01/2022
2Critical Care (Surgical Intensive Care)
12/2020 - 12/2016